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In addition, it is during this time that origins of common adult diseases such as hypertension, coronary heart disease, type 2 diabetes, and depression may develop, which are also sexually dimorphic [ 23 , 24 ]. Metabolism-associated upregulated genes in males were primarily involved in response to nutrient deficit. These genes may be critical markers of sex differences in fetal growth and development that transcends into adulthood determining sex differences in adult diseases, known as fetal origins of adult diseases. Cloning and characterization of a novel human histone deacetylase, HDAC8.
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Ullu E, Weiner Sex. Several placenta-enriched genes as well as dating genes were identified to be unique to the first trimester and common to both sexes. It is a Zapala regulated state of active cell proliferation, cell migration, and cell differentiation [ 5 ].
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